Effect of an iris-fixated intraocular lens on corneal metabolism: a numerical study

How to Cite

Davvalo Khongar P, Pralits JO, Cheng X, Pinsky P, Soleri P, Repetto R. Effect of an iris-fixated intraocular lens on corneal metabolism: a numerical study. MAIO [Internet]. 2018 Jun. 18 [cited 2024 May 22];2(2):97-101. Available from: https://www.maio-journal.com/index.php/MAIO/article/view/81

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aqueous flow; corneal metabolism; intraocular lens


One of the possible risks associated with the implant of iris-fixated phakic intraocular lenses (pIOL) is loss of corneal endothelial cells. We hypothesize that this might be due to alterations in corneal metabolism secondary to the lens implantation. To verify the feasibility of this assumption, we propose a mathematical model of the transport and diffusion of metabolic species in the anterior chamber and the cornea, coupled to a model of aqueous flow. Results are obtained both with and without the pIOL in the case of closed eyelids. The results suggest that glucose availability may be significantly reduced at the corneal endothelium. However, it must still be verified whether this finding has clinical relevance.



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