From your kidneys to your eyes: lessons from computational kidney models
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How to Cite

1.
Stadt MM, Layton A. From your kidneys to your eyes: lessons from computational kidney models. MAIO [Internet]. 2022 Sep. 28 [cited 2022 Dec. 2];4(1). Available from: https://www.maio-journal.com/index.php/MAIO/article/view/121

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Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2022 Melissa Stadt, Anita Layton

Keywords

computational model; diabetes; epithelial transport; renal physiology; sex differences

Abstract

Purpose: The purpose of this review is to describe computational models that have been developed for studying kidney function and howthese models may be adapted to study the eyes.

Methods: We derive equations for modeling solute andwater transport across epithelial cell membranes in the kidney. These equations describe mass conservation, as well membrane transport via cotransporters, exchangers, and primary active transport.

Results: Wedescribe howcomputational models of renal transport have been applied to investigate kidney function in physiological and pathophysiological conditions.

Conclusion: The computational models herein described for the kidney may be adapted to study ocular functions and dysfunction.

https://doi.org/10.35119/maio.v4i1.121
121 PDF

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