TY - JOUR AU - Montanino, Andrea AU - Angelillo, Maurizio AU - Pandolfi, Anna PY - 2018/06/18 Y2 - 2024/03/29 TI - A mesh-free approach to cornea-aqueous humor interaction during tonometry tests JF - Modeling and Artificial Intelligence in Ophthalmology JA - MAIO VL - 2 IS - 2 SE - ESB ITA DO - 10.35119/maio.v2i2.75 UR - https://www.maio-journal.com/index.php/MAIO/article/view/75 SP - 69-74 AB - <p>The dynamic tonometer test (air-puff test) is an in-vivo investigative procedure routinely utilized in ophthalmology to estimate the intraocular pressure (IOP). A rapid, localized air jet applied on the anterior surface induces the inward motion of the cornea, which interacts with the aqueous humor — filling the narrow space between cornea and iris — and has a strong influence on corneal dynamics. Potentially, this quick and painless test could be combined with inverse analysis methods to characterize the patient-specific mechanical properties of the human cornea. As a step towards this aim, the present study describes a fluid-structure interaction (FSI) approach based on a simplified geometry to simulate the anterior chamber of the eye undergoing the air-puff test. We regard the cornea as a non-linear, elastic, and isotropic membrane described through an analytical model, discretizing the weakly compressible Newtonian fluid with a mesh-free particle approach. Numerical analyses reveal a marked influence of the fluid on corneal dynamics. Additionally, we investigate the possibility of using the test dynamics to estimate IOP.</p> ER -