TY - JOUR AU - Stadt, Melissa M. AU - Layton, Anita PY - 2022/09/28 Y2 - 2024/03/28 TI - From your kidneys to your eyes: lessons from computational kidney models JF - Modeling and Artificial Intelligence in Ophthalmology JA - MAIO VL - 4 IS - 1 SE - Review Articles DO - 10.35119/maio.v4i1.121 UR - https://www.maio-journal.com/index.php/MAIO/article/view/121 SP - AB - <p><strong><em>Purpose:</em></strong> The purpose of this review is to describe computational models that have been developed for studying kidney function and howthese models may be adapted to study the eyes.</p><p><em><strong>Methods:</strong> </em>We derive equations for modeling solute andwater transport across epithelial cell membranes in the kidney. These equations describe mass conservation, as well membrane transport via cotransporters, exchangers, and primary active transport.</p><p><em><strong>Results:</strong> </em>Wedescribe howcomputational models of renal transport have been applied to investigate kidney function in physiological and pathophysiological conditions.</p><p><em><strong>Conclusion:</strong></em> The computational models herein described for the kidney may be adapted to study ocular functions and dysfunction.</p> ER -